spectrophotometric analysis of vardenafil in tablet dosage forms by using electrophilic coupling reagents
Authors
abstract
two new spectrophotometric methods (m1 and m2) are developed for the determination of vardenafil in bulk and in tablet dosage forms. the method m1 involves oxidative coupling of vardenafil with 3-methyl-2-benzothiazolinone hydrazone hydrochloride in presence of ferric chloride in acidic medium yielding green colored chromogen with absorption maxima at 625 nm. the method m2 is based on the oxidation of 4-aminoantipyrine by potassium periodate, which subsequently couples with vardenafil in an alkaline medium to form a red colored product having absorption maxima at 530 nm. the absorbance concentration graphs were rectilinear over the range of 4-40 μg ml-1 for the method m1 and 4-60 μg ml-1 for the method m2. the limit of detection values was found to be 0.044 μg ml-1 and 0.035 μg ml-1 for the methods m1 and m2, respectively. the analytical performance of the developed methods was fully validated as per the guidelines prescribed by international conference on harmonization. the results were found to be acceptable. the application of the proposed methods in the determination of vardenafil in their commercial tablet dosage forms was successful showing good percentage recoveries.
similar resources
Spectrophotometric Analysis of Vardenafil in Tablet Dosage Forms by Using Electrophilic Coupling Reagents
Two new spectrophotometric methods (M1 and M2) are developed for the determination of vardenafil in bulk and in tablet dosage forms. The method M1 involves oxidative coupling of vardenafil with 3-methyl-2-benzothiazolinone hydrazone hydrochloride in presence of ferric chloride in acidic medium yielding green colored chromogen with absorption maxima at 625 nm. The method M2 is based on the oxida...
full textSpectrophotometric Analysis of Vardenafil in Tablet Dosage Forms by Using Electrophilic Coupling Reagents
A.V.V.N.K. Sunil Kumar*, T.V. Reddy and C.B. Sekaran Department of Chemistry, NRI College, Vijayawada, India-520 010 Department of Chemistry, Mallareddy College of Engineering, Secundrabad, India-500100 Department of Pharmaceutical Biotechnology & Pharmaceutical Analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, India-522 601 (Received 16 August 2015, Accepted 13 Januar...
full textApplication of hydrotropic solubilization in spectrophotometric analysis of Esomeprazole and Itopride pharmaceutical combined tablet dosage forms
Two simple, accurate and precise methods for simultaneous estimation of Esomeprazole and Itopride in bulk drug and tablet dosage form have been described. Method-A employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. Method -B is Absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.Beer’s law was obeyed in the con...
full textSpectrophotometric Analysis of Dutasteride in Pure and Tablet Dosage Forms
Four simple and sensitive visible spectrophotometric methods have been developed for the assay of dutasteride. Method I describes the interaction of dutasteride, as an n-electron donor, with chloranil, as a pi-acceptor, in acetonitrile to give reddish orange colored chloranil radical anion with absorption maxima at 525 nm. Method II involves the oxidative coupling reaction of dutasteride with 3...
full textApplication of hydrotropic solubilization in spectrophotometric analysis of Esomeprazole and Itopride pharmaceutical combined tablet dosage forms
Two simple, accurate and precise methods for simultaneous estimation of Esomeprazole and Itopride in bulk drug and tablet dosage form have been described. Method-A employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. Method -B is Absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.Beer’s law was obeyed in the con...
full textapplication of hydrotropic solubilization in spectrophotometric analysis of esomeprazole and itopride pharmaceutical combined tablet dosage forms
two simple, accurate and precise methods for simultaneous estimation of esomeprazole and itopride in bulk drug and tablet dosage form have been described. method-a employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. method -b is absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.beer’s law was obeyed in the con...
full textMy Resources
Save resource for easier access later
Journal title:
analytical and bioanalytical chemistry researchPublisher: iranian chemical society
ISSN
volume 3
issue 1 2016
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023